It is 29.8 (Ref. J. Org. Chem, 1980, 45, 3295).
15.9
The pKa of sulfonic acid is < 0
The conjugate acid is Hydrogen (H2), the pKa of which is 35.
The pKa of HSO4- (the second pKa of H2SO4) is 1.92. The Ka is thus 0.0120
15,7
15.9
the pH of ethanol can be calculated using its pKa value (pKa 15.9) and the Henderson-Hasselbalch equation. pH = pKa - log [AH/A] where [AH/A] the ratio of disassociated versus undisassociated species in solution.
In organic solvents (DMSO, ethanol, chloroform, methylene chloride). The most common solvent used to dissolve cyclosporine is DMSO. Water will not work very well.
It is best dissolved in DMSO but 100% ethanol also can be used.
ethanol does not dissociate as much in solution as much as HCl , look up there pka values in future
Soluble in acetone, dimethyl formamide, DMSO, dichloromethane, 100% ethanol or methanol; sparingly soluble in water.
1. If the compound is soluble in diethyl ether, water wash will completely remove DMSO from the ethereal solution . 2. Otherwise, add little ethanol/ water to the sample, then freeze it at -50 degrees Celsius and lypolise it under high vacuum condition (0.01mm Hg or below).
hydrogen fluoride Alcohols like methanol, ethanol. Solvents like dimethyl formamide (DMF) or dimethyl sulfoxide (DMSO)
salt
pKa=40
how do you calculate pKa
One difference is that DMSO-d6 is going to cost more. Chemically speaking, the diffference is that the hydrogens in the -d6 variety have been replaced by deuterium.