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At intersection of north-south (Nile) and east-west (Saharan-Red Sea) trade routes.
At northern limit of summer rain zone, allowed for cultivation without extensive mechanical irrigation.
Iron ore deposits in nearby hills.
Benefits from proximity to ancient civilizations to north, but is just out of reach of possible invaders from north coming down Nile (city is beyond the 5th cataract). Old Kush capital of Napata, farther down river, was more vulnerable.
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