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Overdominance is when the heterozygote has an advantage over both the recessive and dominant homozygotes. Sickle cell disease is an example of this. When the individual is homozygous for the sickle cell allele, sickle cell disease is shown. When the the individual is homozygous for the wildtype allele, they appear normal. However, when the individual is heterozygous, he or she appears normal and will also be resistent to malaria.
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