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It is two step chemical process. In a first step p-toluene-sulphonamide is reacted with methyl chloroformate to yield carbamate intermediate which is in the second step in a condensation reaction with N-amino-3-azabicyclo (3,3,0) Octane hydrochloride converted to crude gliclazide. After crystallization from methanol pharmaceutically pure gliclazide is obtained.

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