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Not necessarily. Whether to use a comma at all is a matter of style, not grammar. Some style guides suggest using a comma before and only if three or more items are listed (sugar, spice, and everything nice). Other style guides don't recommend using the comma (sugar, spice and everything nice). Commas are rarely used in a list of just two items (dogs and cats).

A comma after the word and is rare, but may occasionally occur if there is some phrase after and that needs to be set off: And, I say to you, go forth and conquer! And, Joey, you go with Martha.

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16y ago

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