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There are several expressions that can accomplish this. The most basic is "¿Cómo estás?" (for someone who is familiar) or "¿Cómo está usted?" for a more formal situation. Another informal espression is "¿Qué tal?", basically translated as "what's up?" You can also use "¿Qué pasa?" or "what's happening". There are others, some of which are regional or local idioms. Those three will work in any locality,though.

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13y ago

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