To say "I am from Greenville, South Carolina" in Spanish, you would say, "Soy de Greenville, Carolina del Sur." This phrase directly translates your origin while maintaining the proper names of the location.
Carolina del sur
Norte Carolina, gracias
Carolina (pronouned car-oh-lee-nuh)
As of the mid-2017, Charleston slightly grew larger than Columbia. If you hear anyone say Greenville is the biggest, they may be referring to the metropolitan area. Charleston does have the smallest metro area out of the three main cities of South Carolina.
To say North in Spanish, you say Norte.
sur
Caroline du Sud
espanol
Sudáfrica
La Caroline du Sud
media sur
sur America