You could say 'muy guapo' (presuming you are talking about a man) or to really emphasis how handsome someone is, you could say 'guapísimo'.
Si, eres muy guapo
guapo is Spanish for handsome
Tu hermano es muy guapo.
You can say "guapo" to call a guy handsome in Spanish.
You're welcome handsome in Spanish is three simple words. To say "You're welcome handsome" in the Spanish language would simply be "de nada guapo" and can be easily said.
¡Que guapo!
eres guapo
You can say "ellos son guapos".
very handsome
Hijo guapo Hijo = son guapo = handsome
"¿Cómo estás, guapo/a?"