There are two answers to this question: 1) worth the most points on the tile 2) get used in the best words Q (10) and Z(10) are the letters that are worth the most each, but S(1) and [Blank](0) are the most valuable tiles, because they lead to the best words.
These three 6-letter words are your best bet:innateneatenteniae
12 points: heugh10 points: hunh
These could very greatly depending on how you play your letters. H = 4 U = 1 N = 1 T = 1 I = 1 N = 1 G = 2 Total: 11points (minimum, with no special tiles) The best score is achieved through playing the triple word score and getting the "H" on a double letter score give you a total of 45points
Brine is actually a word. It is a synonym for ocean or sea
4-letter wordsfuji, thio, thou, tofu
The highest word score ever recorded in an official Scrabble tournament was "quixotry". The word was played by Michael Cresta in 2006 winning him 365 points in a single move.
best score:139 against Australia
300 is the best score
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the best score that i have herd is 440
Xavier Hartzel is known for the best IQ score in the world with a 237!