A common meaning for it would be "excellent and skillful assistant". The 'suke' part of the name is common being used in ninjas' names, meaning 'help, assistant'.
Another could be 'great leader'.
[Names aren't supposed to always bear a meaning, in case of Japanese names there are almost always more than few ways to write a name, on which the possible meaning conveyed by the name totally depends.
Another matter is that simply knowing the meaning behind the names' consisting "kanji" doesn't essentially enable one to put together a meaning, or a correct one at least.]
Keisuke Honda
Daisuke Matsui Shunsuke Nakarmura Keisuke Honda
Minami Keisuke was born on July 3, 1985.
Keisuke Okada is 176 cm.
Keisuke Hoashi is 5' 6".
Keisuke Horibe was born in 1966.
Keisuke Horibe is 178 cm.
Keisuke Honda is 182 cm.
Keisuke Hatsuta is 168 cm.
Keisuke Yoshida was born in 1975.
Keisuke Suzuki was born in 1977.
Keisuke Ito was born in 1803.