A common meaning for it would be "excellent and skillful assistant". The 'suke' part of the name is common being used in ninjas' names, meaning 'help, assistant'.
Another could be 'great leader'.
[Names aren't supposed to always bear a meaning, in case of Japanese names there are almost always more than few ways to write a name, on which the possible meaning conveyed by the name totally depends.
Another matter is that simply knowing the meaning behind the names' consisting "kanji" doesn't essentially enable one to put together a meaning, or a correct one at least.]
Keisuke Honda
Daisuke Matsui Shunsuke Nakarmura Keisuke Honda
Minami Keisuke was born on July 3, 1985.
Keisuke Kihara was born in 1939.
Ōtori Keisuke died in 1911.
Ōtori Keisuke was born in 1833.
Keisuke Miyagi was created in 1984.
Keisuke Ito was born in 1803.
Keisuke Ito died in 1901.
Keisuke Suzuki was born in 1977.
Keisuke Ishida was born in 1955.
Keisuke Kato was born in 1988.