It helps if you supply more context than just a short phrase. "Tío" generally means "uncle", but can mean "guy" or "pal" depending on context. "Esta" as written means "this". "Está" means "it/she/he is". "Listo" can mean "clever" or smart, but can also mean "ready". "Lista" would mean "list" or "smart" or "ready" when applied to a female.
With this in mind, the phrase could mean "Uncle is smart", "the guy is ready" or even "this guy list" if a little misspelling is appled.
Uncles
It means Uncle
Tio mean uncle in spanish
uncle
It means "It hurts that I can't see my uncle"
tio estas hondo = you're deep, fellow/man/guy/dude (tio also means 'uncle')
Uncle
i am an uncle
It stands for uncle.
"Un tío" in English translates to "a guy" or "a dude." It is a Spanish slang term commonly used to refer to a man or guy in a casual or colloquial way.
How old is your uncle? ('tio' could also mean 'bloke, fellow')
Qual o nome de seu tio favorito? in Portuguese is "What is your favorite uncle's name?" in English.