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The presumption from the question is that you have just lost your brother, and she has just lost her husband. We are sorry for your loss. One thing to say at times like this, that would be appropriate under just about any circumstances, is "I'm so sorry for your loss". After that, the conversation will just follow its natural course. After all, you must know each other at least to some extent.

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13y ago

What else can I help you with?