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René-Robert Cavelier, Sieur de La Salle, faced numerous challenges during his explorations, including hostile relations with Indigenous tribes, harsh weather conditions, and limited supplies. His ambitious quest to navigate the Mississippi River and establish a French presence in the region was often hindered by difficult terrain and navigational difficulties. Additionally, internal conflicts among his crew and the logistical challenges of maintaining a supply line added to the obstacles he encountered. Despite these hardships, La Salle's determination ultimately led to significant discoveries in North America.

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