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There is no connection. The mastodons were hunted to extinction in the Old World over 10,000 years before agriculture developed. The only tenuous connection is that without large mammalian herbivores to hunt, mankind had to domesticate animals and grow crops to replace the foods source lost. Considering that there was such a large interim, however, the extinction of mastodons and mammoths cannot be the sole or most important cause in this.

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