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The thymus contains large numbers of T cells and scattered dendritic cells, epithelial cells and macrophages. Immature T cells migrate from red bone marrow to the thymus, where they multiple and begin to mature. Lymph nodes filter lymph, which enters a node through one of several afferent lymphatic vessels. As lymph flows through the node, foreign substances are trapped by reticular fibers within the spaces between cells. Macrophages destroy some foreign substances by phagocytosis and lymphocytes destroy other by a variety of immune responses. Plasma cells and T cells that have divided many times within a lymph node can also leave the node and circulate to other parts of the body.

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