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A combination of genetic and environmental factors play a role in the development of schizophrenia.[2][3] People with a family history of schizophrenia who suffer a transient psychosis have a 20-40% chance of being diagnosed one year later.[23]

Estimates of heritability vary because of the difficulty in separating the effects of genetics and the environment.[24] The greatest risk for developing schizophrenia is having a first-degree relative with the disease (risk is 6.5%); more than 40% of monozygotic twins of those with schizophrenia are also affected.[3] It is likely that many genes are involved, each of small effect and unknown transmission and expression.[3] Many possible candidates have been proposed, including specific copy number variations, NOTCH4, and histone protein loci.[25] A number of genome-wide associations such as zinc finger protein 804A have also been linked.[26] There appears to be significant overlap in the genetics of schizophrenia and Bipolar disorder.[27]

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Related Questions

Is schizophrenia autosomal recessive or dominant?

Schizophrenia is only partially genetic, and therefore is neither recessive nor dominant.


If a 30 year old has schizophrenia could the mother have it as well?

Yes. Schizophrenia is partly genetic, meaning that if you have a relative with schizophrenia you are likely to also have schizophrenia. About 1/10 of people with a relative with schizophrenia develop schizophrenia, compared to 1/100 people without a relative with schizophrenia.


What part of the brain are associated to schizophrenia?

None, because schizophrenia is a condition determined by checklists and psychiatrists. It is not a condition derived from physical brain damage.


Why is schizophrenia called DID?

It's not. DID is an acronym for Dissociative Identity Disorder. This is a very different condition from schizophrenia.


In what psychiatric condition is Halloperidol used?

Schizophrenia


Are gentic abnormalties suspected causes in alzheimers and schizophrenia?

Genetic abnormalities


How likely is schizophrenia hereditary?

Schizophrenia is partly genetic- one out of ten people who have at least one schizophrenic relative also have schizophrenia (compared to one out of one hundred people in general). About one out of two people whose identical twins have schizophrenia also have schizophrenia. However, schizophrenia is not completely genetic. If schizophrenia was completely genetic, everyone who had an identical twin with schizophrenia would also have schizophrenia. This is not the case. Like I said before, about 50% of people whose identical twins have schizophrenia also have schizophrenia. There are environmental as well as genetic factors to schizophrenia.


Is schizophrenia terminal?

Schizophrenia is a mental disorder. It is not a condition that causes any sort of physical sickness that would lead to death.


Do people with schizophrenia remember what they do if they have an psychotic episode?

Typically yes, but it varies from person to person and condition to condition (schizophrenia isn't actually just one disorder--it's a spectrum of disorders).


Are there other names for schizophrenia?

At one point, schizophrenia was called "dementia praecox". Some people may say that "multiple personality disorder", "split personality", or "dissociative identity disorder" are other names for schizophrenia. However, the condition that these names describe is not the same as schizophrenia.


How does psychosis in schizophrenia happen?

Psychosis in schizophrenia and perhaps schizophreniform disorder appears to be related to abnormalities in the structure and chemistry of the brain, and appears to have strong genetic links


What is the difference in the expression of schizophrenia in identical twins attributed to?

The difference in the expression of schizophrenia in identical twins is attributed to a combination of genetic and environmental factors. While identical twins share the same genetic makeup, environmental influences such as stress, trauma, or drug use can lead to differences in the onset and severity of schizophrenia symptoms between twins.