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The selection of an internal standard (IS) in the LC-MS/MS method development for montelukast is crucial for ensuring accurate quantification and compensation for variability in sample preparation and instrument response. An ideal IS should possess similar chemical properties to montelukast, such as similar polarity and ionization behavior, while being structurally distinct to avoid interference. Common choices include deuterated analogs of montelukast or chemically similar compounds that do not occur in biological samples. The IS should also be easily detectable and have a stable response across the expected concentration range.
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What does LCMSMS mean on a hair follicle test results?
Liquid chromatography--tandem mass spectrometry. It's just telling you the machine they did the test on.
Nitrofurantoin method development in lcmsms and linearity range?
LCMSMS-3200 LINEARITY RANGE:5-800 ng/mL EXT PROCEDURE:0.250 mL +50µL ISTD(Nitrofurantoin 13c3)+2.5 mL Ethyl acetate)-vortex,centrifuge and transfer 2.0 mL supernaunt and evaporate till dry at 40C and reconstitute 0.250 ml Mobile phase(10 mM ammonium acetate :MeoH-5:95) column:phenyl column-c18
