What is the usage of N-CBZ-L-proline?
Chiral pyrrolidine derivatives, containing 5-membered azaheterocycle enantiomeric intermediates are valuable in asymmetric synthesis for pharmacology.N-Carbobenzoxy-L-proline can be used for the synthesis of biochemical reagents, the synthesis of valacyclovir side chains, the synthesis of vasopressin and other polypeptide.N-Cbz-4,5-dehydro-l-prolineamide or N-Boc-4,5-dehydro-l-prolineamide are alternative key intermediates for the synthesis of saxagliptin, a dipeptidyl peptidase IV (DPP4) inhibitor recently approved for treatment of type 2 diabetes mellitus.