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An antibody (IgM for example is a pentamere), can consist out of more than one different immonoglobulines. One of the variabel regions of these immunoglobulines can bind to an epitope of an antigene, this is called affinity. When different variabel regions of one antibody bind to different epitopes on an antigene, the combined effect is called avidity. The effect is not equal to the sum of the affinity's.

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