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If the 'ac' ends the word, then it is a suffix, not a prefix. Prefixes by definition are added to the beginning of a root word.

But as a suffix, '-ac' is the adjectival ending derived from the Greek, and therefore means "of, related, or pertaining to [the root]." Thus 'amnesia' becomes the adjective 'amnesiac', and the noun 'mania' becomes the adjective 'maniac'.

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