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In Electronics,mono means designating sound transmission, recording or reproduction over a single channel.

Mono (noun) : An acute disease characterized by fever and swollen lymph nodes and an abnormal increase of mononuclear leucocytes or monocytes in the bloodstream; not highly contagious; some believe it can be transmitted by kissing.

In combination form: Mono means One, single.
A disease called mononucleosis, or that your sound system is not playing in stereo.

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