Benzoylation is a type of substitution reaction in which the hydrogen of amide group or hydroxy group of aromatic benzene group take place.
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Sodium hydroxide (NaOH) is used as a base in benzoylation reactions of amines to deprotonate the amine, forming the corresponding amine salt. This salt formation helps to make the amine more reactive towards the benzoyl chloride reagent, facilitating the acylation step. NaOH also helps to maintain the reaction environment at a basic pH, which is ideal for the reaction to proceed efficiently.
NaOH is used in the benzoylation process to neutralize the byproduct, hydrochloric acid, that is formed during the reaction between benzoyl chloride and the compound being benzoylated. This helps to maintain the overall pH of the reaction mixture and prevent any unwanted side reactions. Additionally, NaOH can help to promote the formation of the desired benzoylation product.
A benzoylation is a reaction which introduces a benzoyl group into a molecule.
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