handmade
Natural formation.
If you are referring to synthetic meaning "man-made", then the opposite would be "natural" or "genuine". There is another usage of synthetic, in which the opposite is "analytic".
The opposite of aggravated (upset) could be peaceful or unbothered.The opposite of the past tense verb form (made worse) would be improved or alleviated.
The opposite of "improved" is "worsened" or "deteriorated." When something is improved, it means it has been enhanced or made better in some way. Conversely, when something is worsened, it means it has declined in quality or performance. Therefore, the opposite of improved is a decrease in quality or value.
An opposite of the word "to" is from.
The opposite of hand made is machine made.
The opposite of made is "destroyed".
The opposite of hand made is machine made.
Well made.
A person or thing has either not made a debut, is making a debut, or has already made a debut.... there is no opposite.
The opposite of a sale is a purchase (normally both are made concurrently).
The opposite of naturally occurring would be artificially created or man-made.
Natural formation.
squidward
Incompatible.
Natural formation.
he has made no announcement of the opposite.