In the US
The largest standard men's size is 15-16 (UK 14) but sizes to 22 are commercially available.
Mondopoint
The ISO standard (used by NATO and many international concerns) defines the length and width of the foot numerically, in millimeters. For US Men's size 15, the equivalent Mondopoint is 320 (shoe length averages 335 mm).
(see related link for size charts)
the size 66 was worn by the worlds tallest man in recorded history (size 37AA in American sizes )
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In most retail stores, the largest sizes available are a size 11 for women and 18 for men. The largest shoes ever made however, were made for a man named Robert Wadlow. His shoes were a size 37AA and were 18.5 inches long.