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It is rare for normal labor to exceed 24 hours between delivery of multiple babies. This is because at birth, the mother's body undergoes changes that would make it difficult for any babies to continue relying on the placenta and umbilical cord.

However, when very premature births occur, it may be possible to have prolonged durations. In 2013, a mother in Ireland gave birth at 23 weeks to one fraternal twin, but the other remained in the womb for another 87 days, with labor induced at week 36. One twin daughter was born on June 1, 2012, the other on August 27, and both survived. The first, however, defied high odds against survival and spent the intervening three months in an incubator.

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