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"Earthquakes can affect a wide area and cause much destruction."

"We don't know how the school changes will affect our schedule."

Using affect and effect

Affect means to have an influence on something. Affect is usually a verb.

Effect is the result of an influence or change. Effect is usually a noun.

Compare examples:

The experience would affect my later life. (verb)

The experience had a strong effect on me. (noun)

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