Your great uncle is the brother of your grandmother or grandfather. Therefore you and your great uncle's grandson share one or two great grandparents, and you are both the same number of generations separated from that shared ancestor.
So you are second cousins to each other.
He would be your great-great uncle.
Your grandson is the great-nephew of your brother.
Your grandfather's brothers would be the uncles of your parent. That would make them your great uncle.
You Aunt is you grandson's Great-Great Aunt. Your grandson is your Aunt's Great-Great Nephew.
Your brother is a great great uncle to your great grandson. Your great grandson is your brother's great great nephew.
What is your great-great-great grand nephew?!
Your great aunt's grandson is your second cousin.
Your sister is your grandson's great aunt. He is her great nephew.
Your niece's grandson is are your great-grandnephew.
She would be your great grandmother
Your sister's great grandson is your great great nephew. You are his great great uncle, or great great aunt.
Your great aunt's great grandson is your second cousin, once removed.