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Although the theme has been explored in Science Fiction (e.g. "The Fly", "Splice"), it is not something that is straightforward or simple. The genetic process has safeguards that will usually prevent such hybrids. Even when the cells survive and divide, the resulting cells may not specialize and mature.

Because of ethical and legal restrictions, human experimentation is limited. DNA or gene therapy has provided some valuable medical procedures.

The use of DNA transfer among non-human animals has been widely studied, and bacterial forms are widely used in research and industry.

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