Audrey Tautou
Helen Hunt played the female lead, Dr. Jo Harding, in the movie "Twister."
Leslie Caron
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Audrey Hepburn played the lead, female role.
Rachel Ward played the female lead, Meggie Cleary, in the TV mini-series "The Thorn Birds."
Yami Gautam had the lead female role. It was her Bollywood debut.
Mary Martin played Ensign Nellie Forbush who was the lead.
Jean Simmons
Lily Rush played by Kathryn Morris is the female lead. Lily
Lesley Ann Warren played Lula Rogers.
In South Pacific (1958), the male lead was played by Rossano Brazzi, with Mitzi Gaynor in the female lead.
The female lead in Pearl Harbor was actress Kate Beckinsale, who played the character of Nurse Lt. Evelyn Johnson.