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Vitamin E is hydrophobic and is absorbed similarly to other dietary lipids. After solubilization by bile acids, it is absorbed into small intestinal epithelial cells, incorporated into chylomicrons, and transported into blood via lymphatics.

Once in the circulation, vitamin E is liberated from chylomicrons and much is taken up by the liver, where it is repackaged into very low density lipoproteins and secreted again into blood. Ultimately, vitamin E is transported in blood bound to a variety of lipoproteins, from which it is taken up by tissues throughout the body. Vitamin E is stored within the fat droplets of adipose tissue cells.

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