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Cyclobenzaprene, the generic form of Flexeril, which is a skeletal muscle relaxant, can increase the effects of certain nasal decongestants. I don't know which ones are in Nyquil, (you can read the label to see which ones are in it), but the nasal decongestants that it can increase the effects of are: naphazoline, oxymetazoline, phenylephrine, and xylometazoline.

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17y ago

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