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When you say toxin, I am assuming you mean organic toxins from bacteria or viruses. In general toxins are not destroyed by cooling.

On the other end, a high enough temperature can destroy any organic toxin; so, heat stability is a relative term that is reserved for those toxins that can remain active at temperatures where most other toxins would be irreversibly deactivated.

Some examples of heat stable toxins are: enterotoxin from Staphylococcal enteritis, ciguatoxin-CTX1B from Gambierdiscus toxicus, and the antigen CD24 from B-lymphocytes.

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