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Household detergents can negatively impact jello by breaking down its Gelatin structure, which is essential for its firmness and stability. When detergent is mixed with jello, it can cause the gelatin to lose its ability to gel properly, resulting in a watery or soupy consistency. Additionally, the presence of detergents may introduce unwanted flavors or chemicals, making the jello inedible. Thus, it's best to avoid any contact between jello and household cleaning products.

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