Can you take fenuthyme with hydrocodone?
no interactions found...but grapefruit juice..GENERALLY AVOID:
Grapefruit juice can inhibit CYP450 3A4 and may theoretically
increase the plasma concentrations of fentanyl, which is primarily
metabolized by the isoenzyme. According to some manufacturers,
concomitant use of fentanyl with CYP450 3A4 inhibitors including
grapefruit juice can increase or prolong adverse drug effects and
may cause potentially fatal respiratory depression. Clinical data
are limited. In a study with 12 healthy volunteers, consumption of
250 mL regular-strength grapefruit juice the night before and 100
mL double-strength grapefruit juice one hour before administration
of oral transmucosal fentanyl citrate (600 or 800 mcg lozenge) did
not significantly affect fentanyl pharmacokinetics, overall extent
of fentanyl-induced miosis (miosis AUC), or subjective
self-assessment of various clinical effects compared to control.
However, pharmacokinetic alterations associated with interactions
involving grapefruit juice are often subject to a high degree of
interpatient variability. The possibility of significant
interaction in some patients should be considered.
MANAGEMENT: Although clinical data are limited, consumption of
grapefruit and grapefruit juice should preferably be avoided during
treatment with fentanyl. Patients and/or their caregivers should be
advised to seek medical attention if potential signs and symptoms
of toxicity occur such as dizziness, confusion, fainting, extreme
sedation, bradycardia, slow or difficult breathing, and shortness
of breath. Patients treated with transdermal formulations of
fentanyl should be cautioned that drug interactions and drug
effects may be observed for a prolonged period beyond removal of
the patch, as significant amounts of fentanyl are absorbed from the
skin for 17 hours or more after the patch is removed.