Are Mickey Mouse and Minnie Mouse related?

Answer 1

In the official canon they have not been stated as blood related to Daisy. However, Don Rosa has suggested that Daisy is their father's sister which would be why the boys constantly call her 'aunt Daisy'. This makes Donald's nephews also Daisy's nephews but just from the other parent's side. But hence, that is ONLY in Don Rosa's personal vision. Because although Disney has stamped his stories and makes money with them, they're his original stories, as in Disney has nothing to do with them apart from the characters he uses and the inspiration he gets from their original creators.

Answer 2

Mickey Mouse and Daisy Duck are good friends

Answer 3

No.