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If you mean, if they can have a GENTLE nature, then yes that's possible. Simply put a Pokemon that has the Sychronize ability and has the Gentle nature up first, and when you fight Mewtwo in some game, whether from FireRed or LeafGreen, or used the wild Pokemon modifier in Emerald, Diamond or Pearl versions, have the Pokemon first and hit Mewtwo at least once. Then when you catch Mewtwo, the chance of it having the Gentle nature is increased by at least 50% or so.

If you mean, by pokedex, then I don't think so. Try to specify your questions next time, alright~?

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13y ago

What else can I help you with?