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Philip II ruined his relationship with his son, Alexander the Great, by rejecting Alexander's mother who was a Greek from Epirus and marrying another woman who was a Greek from Macedonia. Alexander, and especially his mother, felt that Alexander would no longer be in line to inherit the throne should Philip II die with an heir that was a full Macedonian Greek. There have been speculations that Alexander had killed his father but in light of this reason, it has been proposed that it was Alexander's mother that may have arraigned to assassinate Philip, not Alexander.

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