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Calypso cannot be found through normal gameplay and isn't even part of the storyline. She can be found in the warehouse after completing Chapter 15; she is very hard to get to. You can fight her in Boss round 4. She will be accompanied by seven masked henchman who appear to be distorted like the fake spidermen from the "Funhouse of Doom". They can be easily beaten like normal henchmen and do not carry guns. You can unlock the boss rounds by completing Endurance round 3. Endurance round 3 features seventy-five henchman with Shocker's and Doctor Octopus's henchman in the mix. It can be defeated by grappling each henchman individually and defeating them in a secluded spot. Note: the endurance rounds can only be unlocked by completing Round 3 of the first challenge.

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Q: How do you fight calypso on Spider-Man 2 game?
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