How does Huntington's start in a family?

Answer 1

Huntington's disease is an inherited genetic disorder caused by a mutation in the HTT gene, which encodes the huntingtin protein. It follows an autosomal dominant inheritance pattern, meaning that an affected individual has a 50% chance of passing the mutated gene to each offspring. Symptoms typically begin in mid-adulthood, but the age of onset can vary widely among individuals. As a result, Huntington's can appear to start in families when the gene mutation is passed down through generations.