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Yes they are friends. George Clooney guest stared on Friends for 1 episode as a cute ER doctor. Friends and ER sets were near by each other. In addition, Clooney stared in Ocean's Eleven and Ocean's Twelve with Aniston's then husband Brad Pitt. Also Aniston participated in Clooney's telethon to help Haiti.

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Q: Is Jennifer Aniston friends with George Clooney?
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