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The five conditions of Hardy-Weinberg equilibrium are: 1) a large population size to minimize genetic drift, 2) random mating to ensure equal opportunity for all individuals to reproduce, 3) no mutations to prevent changes in allele frequencies, 4) no migration to eliminate gene flow between populations, and 5) no natural selection to ensure that all alleles confer equal fitness. If these conditions are met, allele and genotype frequencies in a population will remain constant over generations.

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