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Charlesfort and San Miguel de Gualdape were both early Spanish attempts at establishing settlements in North America during the 16th century. Charlesfort, founded in 1562 on the coast of present-day South Carolina, and San Miguel de Gualdape, established in 1526 in present-day Georgia, both faced challenges such as harsh conditions, lack of supplies, and conflicts with Indigenous populations. Ultimately, both settlements were abandoned, reflecting the difficulties of European colonization in the region. Their failures highlight the precarious nature of early colonial endeavors in North America.

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