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Yes.Unfortunately it does after an experiment with the a vacine.

Its not from an experiment that the dog dies. It is attacked by other dogs which have the disease while protecting Will Smith

Another answer:Both answers above are partly right but slightly off. After unsuccessfully trying to save it (the "experiment with a vaccine"), Will Smith's character actually has to kill the dog himself when it becomes feral after being attacked by the diseased dogs. Smith's acting in that scene is truly outstanding.
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14y ago

What else can I help you with?