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Hoffman's degradation of amides is a chemical reaction that involves the conversion of an amide into a primary amine with one fewer carbon atom. This is achieved by treating the amide with bromine (Br2) in the presence of a strong base, typically sodium hydroxide (NaOH). The reaction proceeds through the formation of an isocyanate intermediate, which subsequently hydrolyzes to yield the primary amine and carbon dioxide. This process is useful in organic synthesis for generating amines from more complex amide structures.

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2d ago

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What has the author Jean Hoffmans written?

Jean Hoffmans has written: 'La philosophie et les philosophes'


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Amides are electron withdrawing in chemical reactions.


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It all depends on what you mean. Neither form is correct if you simply want to refer to a family called Hoffman."The Hoffmans lived next door to me when I was a child." (A family whose surname was Hoffman lived next door to me.)"I used to like going to the Hoffmans' house." (I liked going to the house that belonged to the Hoffmans.)"I used to like going to the Hoffmans'." (Same meaning as above - the word 'house' or 'place' is understood.)"I used to like going to the Hoffmans." (No apostrophe - the meaning is that I liked going to that family - the people not the house are being referred to.)"I liked visiting the Hoffmans." (I liked visiting the family called Hoffman.)"Hoffman's house was very big." (The house that belonged to a person called Hoffman was very big.)"The Hoffman's car was brand new." (This usage would mean that the car belonged to someone known as 'The Hoffman' - a nickname.)If the family name ends in s [Hoffmans] the apostrophe goes behind the s , otherwise we have the Hoffmanses. The Hoffman's is a possessive pronoun.The Hoffmans' is a plural pronoun.Re the above: Neither The Hoffman's nor The Hoffmans' is a pronoun. They are both nouns, and both possessive nouns.


Who was Dustin Hoffmans co star in the graduate?

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no, not in any way.


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Amides are generally not flammable. As for their smell, it can vary depending on the specific amide compound. Some amides may have a faint ammonia-like odor, while others may be odorless or have different, often mild, odors.


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Why amides are soluble in water?

Amides are soluble in water because they can form hydrogen bonds with water molecules due to the presence of a carbonyl group and an amine group. This ability to interact with water molecules through hydrogen bonding allows amides to be soluble in water.


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Cyclic amides, also known as lactams, are compounds with a ring structure containing an amide functional group. They have unique properties that make them useful in organic chemistry. Cyclic amides are commonly found in natural products and pharmaceuticals due to their stability and ability to form hydrogen bonds. They are also used as building blocks in the synthesis of complex molecules. Additionally, cyclic amides can exhibit different reactivity compared to linear amides, making them valuable in various chemical reactions.