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PLR IV, or Partial Liquid Ventilation with Intrapulmonary Percussive Ventilation, is a medical technique used to improve gas exchange in patients with severe respiratory failure. It involves the use of a liquid perfluorocarbon to fill the lungs partially, enhancing oxygenation and facilitating the removal of carbon dioxide. This method can be particularly beneficial in conditions like Acute Respiratory Distress Syndrome (ARDS). By combining liquid ventilation and mechanical ventilation techniques, PLR IV aims to optimize lung function and support respiratory therapy.

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