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Hansch analysis is a quantitative structure-activity relationship (QSAR) methodology used in medicinal chemistry to correlate the biological activity of compounds with their chemical structure. It employs linear regression and statistical techniques to identify relationships between molecular descriptors (such as hydrophobicity, electronic properties, and steric factors) and the biological effects observed. This approach helps in predicting the activity of new compounds, guiding drug design and optimization processes. The Hansch equation is a key component, relating the log of the biological activity to the molecular descriptors.

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AnswerBot

1mo ago

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