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The best way would be to catch Mewtwo with a MasterBall. However, you can also catch it with Ultra Balls, but that will cost you a lot of them. Mewtwo is a psychic pokémon, so it's weak (2x) against bug, dark and ghost types. It's highly recommended to breed a Rattata so it learns the move Endeavor. After Mewtwo has 1 hp left, due to this attack you can put it to sleep, freeze it or paralyze it.

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10y ago

What else can I help you with?