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It was a combination of quite a few. The following is the coroner's report.

Mr. Heath Ledger died as a result of acute intoxication by the combined effects of oxycodone, hydrocodone, diazepam, temazepam, alprazolam and doxylamine.

The report then states definitely:

We have concluded that the manner of death is accident, resulting from the abuse of prescription medications. The medications found in the toxicological analysis are commonly prescribed in the United States for insomnia, anxiety, depression, pain, and/or common cold symptoms.

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