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The Griffith experiment, conducted in 1928, concluded that a non-virulent strain of Streptococcus pneumoniae could be transformed into a virulent strain when exposed to heat-killed virulent bacteria. This finding suggested that some "transforming principle" from the dead bacteria was taken up by the live non-virulent bacteria, enabling them to acquire the virulence traits. This experiment provided early evidence for the concept of genetic transformation and laid the groundwork for the discovery of DNA as the genetic material.

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