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Yes. Since Deadpool was cursed by Thanos, possibly there is a way to cancel the curse of life implanted on Deadpool. But even without the curse, Deadpool still has a advanced healing factor which is even stronger than Wolverine's. If someone could go back in time before Wade was given the healing factor and kill him, they would kill him and Deadpool would never exist. Or they can decapitate his head and dismember all his arms and legs and spread them out far, far away in the galaxy or they can throw Deadpool into the Sun or molten lava deep in the Earth and every time he tries to regenerates, his body will burn and even though he is still immortal or he doesn't have the curse, he will suffer extreme pain of his body burning for all eternity or he will die and his body will give up. Also someone could sell Deadpool's soul to Satan and Deadpool would be stuck in Hell forever. So even though you might not really killed him, he will suffer for eternity. Or he could really die. But all together it is up to Marvel.

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10y ago

What else can I help you with?